One of my main themes is the nerd love story. (See, for example, my novel.) The shy, socially-awkward (yet adorable) kid suffers humiliating rejections, but ultimately wins out. For me, this is the most obvious type of underdog story to write. As my parents explicitly taught me, it doesn't matter whether you're popular in high school. If you are the smart kid, then you have the tools to be a success in life.
You may recall one of my many complaints about the Harry Potter series was that despite being unpopular/bullied as a teen, after a certain number of years of being a successful adult, someone like Snape would grow up a bit. Emotionally. Well, there's a short essay by a professor at MIT (making the rounds of the Internet) that suggests I may be wrong on this point.
Amanda Marcotte is right that Laurie Penny is way too nice to this guy (so Amanda compensated by perhaps going too far the other way -- though her piece is quite funny). A personal friend and colleague of my husband also wrote a response that is spot on. But there's one key point that I don't think any of these folks hit on, which I would like to address.
Life is not fair. If you are one of the brainiacs, then you have an unfair advantage over others. Because being one of the smarties endows you with a magical little thing called problem solving skills.
Suppose you look around and you see some guys who logically shouldn't be desirable to women ("Neanderthals" in the above professor's terms) having lots of success attracting women. You believe that what you have to offer to women is actually better, yet women somehow fail to grasp this. If your solution to this conundrum is that women are simply too stupid to act in their own self interest (all of them! Or at least all the ones you might potentially find attractive), so you decide to spend the next twenty years stewing in your own bile over the unfairness of it all, then you are an idiot.
That's the only reason people are responding to this guy's rant, by the way. Stupid, frustrated men who have concluded that the problem is the entire female half of the human race are a dime a dozen. There are whole subnetworks on the Internet devoted to their rantings. Here's a typical example. What makes the professor's essay noteworthy is that people are astonished that someone could be smart enough to be a professor at MIT and yet be dumb enough to make an ass of himself in such a public way.
The thing is that it's not that hard a problem to solve. People of all different desirability levels solve it every day. If your offer is desirable, there are plenty of ways to find the people who will want to take you up on it, and if it's not, there are ways to make your offer more desirable. If you're looking around and wondering "Why him and not me?" -- don't ask it as an angry rhetorical question, ask it as a serious question. And apply your analysis and problem-solving skills to come up with effective strategies to solve it.